Anoctamins

**Definition:** A family of transmembrane proteins that function primarily as calcium-activated chloride channels. Structurally, they form a homodimer where each subunit consists of eight transmembrane helices with the N and C terminals exposed to the cytosol. The regions between helices 5 and 7 may be important for ion pore formation and calcium ion binding.

**Tree numbers:** - D12.776.157.530.400.175.032 - D12.776.543.550.450.175.032 - D12.776.543.585.400.175.032

**Synonyms:** - TMEM16 Proteins - Anoctamin - TMEM16 Protein Family