COP9 Signalosome Complex

**Definition:** A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

**Tree numbers:** - D05.500.139 - D08.811.037.750.250 - D08.811.277.656.300.887.375

**Synonyms:** - COP9 Signalosome (CSN) - COP9 Signalsome - Constitutive Photomorphogenesis 9 Signalsome - Constitutive Photomorphogenesis 9 Signalosome