NEDD8 Protein

**Definition:** A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins

**Tree numbers:** - D12.776.947.218

**Synonyms:** - NEDD-8 Protein - Ubiquitin-like Protein NEDD8 - Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8