Promyelocytic Leukemia Zinc Finger Protein

**Definition:** A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

**Tree numbers:** - D12.776.260.522.625 - D12.776.930.375.625

**Synonyms:** - Promyelocytic Leukaemia Zinc Finger Protein - ZBTB16 Protein - PLZF Protein - Zinc Finger and BTB Domain Containing 16 Protein