Cell Adhesion Molecule-1

**Definition:** A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.

**Tree numbers:** - D09.400.430.890.200.115 - D12.776.395.550.200.115 - D12.776.543.550.200.128 - D23.050.301.350.115

**Synonyms:** - CADM1 Protein - IGSF4 Protein - TSLC1 Protein - Tumor Suppressor in Lung Cancer 1 Protein