Disks Large Homolog 4 Protein

**Definition:** A neuronal protein consisting of three PDZ DOMAINS, an SH3 DOMAIN, and a C-terminal guanylate kinase-like region (see MAGUK PROTEINS). It localizes to the POST-SYNAPTIC DENSITY and associates with the cytoplasmic tail of NMDA RECEPTORS and SHAKER POTASSIUM CHANNELS, playing a critical role in NMDA receptor-mediated SYNAPTIC PLASTICITY.

**Tree numbers:** - D08.811.913.696.650.450.750 - D12.644.360.265 - D12.776.476.265 - D12.776.543.219 - D12.776.631.224

**Synonyms:** - Synapse-Associated Protein 90 - Postsynaptic Density Protein 95 - SAP90 Protein - SAP-90 Protein - PSD95 Protein - Discs Large Homolog 4 Protein - PSD-95 Protein