Fanconi Anemia Complementation Group N Protein

**Definition:** A Fanconi anemia complementation group protein that contains an N-terminal DNA-binding region and seven, C-terminal, WD REPEATS. It is an essential factor in HOMOLOGOUS RECOMBINATION DNA REPAIR through its interactions with BRCA2 PROTEIN; RAD51 RECOMBINASE; and BRCA1 PROTEIN. It functions as a molecular scaffold to localize and stabilize these proteins at homologous recombination sites. Mutations in the PALB2 gene are associated with FANCONI ANEMIA complementation group N; type 3 PANCREATIC NEOPLASMS; and susceptibility to BREAST CANCER.

**Tree numbers:** - D12.776.313.953 - D12.776.624.776.051 - D12.776.660.323

**Synonyms:** - Partner and Localizer of BRCA2 Protein - FANCN Protein - PALB2 Protein