WNK Lysine-Deficient Protein Kinase 1

**Definition:** A serine-threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. It functions as an activator and inhibitor of sodium-coupled chloride co-transporters and as an inhibitor of potassium-coupled chloride co-transporters. Mutations in the WNK1 gene are associated with type 2C PSEUDOHYPOALDOSTERONISM and type 2A HEREDITARY SENSORY AND AUTONOMIC NEUROPATHIES.

**Tree numbers:** - D08.811.913.696.620.682.700.982 - D12.776.476.563.982 - D23.050.301.500.600.962 - D23.050.705.552.600.925