MRE11 Homologue Protein

**Definition:** A component of the MRN complex along with Rad50 and Nibrin. Together, these perform a critical function in the repair of DOUBLE-STRANDED DNA BREAKS; RECOMBINATIONAL DNA REPAIR; maintenance of TELOMERE integrity and MEIOSIS. MRE11, which contains a poly(ADP)-ribose binding motif and associates with PARP1, possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Mutations in the MRE11 gene are associated with ATAXIA-TELANGIECTASIA-like disorder 1.

**Tree numbers:** - D08.811.277.352.335.350.650 - D08.811.277.352.335.375.813 - D08.811.277.352.355.325.600 - D08.811.277.352.365.290.250 - D12.776.157.687.495 - D12.776.260.539 - D12.776.660.720.495

**Synonyms:** - Meiotic Recombination 11 Homolog 1 Protein - MRE11A Protein