CCCTC-Binding Factor

**Definition:** A repressor protein with poly(ADP)-ribose binding activity that binds CHROMATIN and DNA; its structure consisting of 11 CYS2-HIS2 ZINC FINGERS allows it to recognize many different DNA target sites. It functions as a repressor by binding to INSULATOR ELEMENTS and preventing interaction between promoters and nearby enhancers and silencers. It plays a critical role in EPIGENETIC PROCESSES, including GENOMIC IMPRINTING.

**Tree numbers:** - D12.776.157.687.157 - D12.776.260.120 - D12.776.660.235.050 - D12.776.660.720.157 - D12.776.664.235.050 - D12.776.930.780.563

**Synonyms:** - CTCF Protein - DNA-Binding Protein CTCF