Centromere Protein A

**Definition:** A 17 kDa, centromeric, poly(ADP)-ribose binding protein that is structurally similar to HISTONE H3 and localizes to NUCLEOSOMES within the CENTROMERE; specifically within the region that binds KINETOCHORES, where it replaces histone H3. It plays a critical role in recruiting kinetochore proteins and progression through MITOSIS, chromosome segregation, and CYTOKINESIS. It also binds sera from patients with some scleroderma-like AUTOIMMUNE DISEASES.

**Tree numbers:** - D12.776.157.687.173 - D12.776.260.123 - D12.776.660.235.100 - D12.776.660.720.173 - D12.776.664.235.100 - D23.050.422.031

**Synonyms:** - CENP-A Protein - Centromere Autoantigens 17K - Centromere Protein 17K - CENPA Protein