Heat Shock Transcription Factors

**Definition:** Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by POLY-ADP-RIBOSYLATION. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.

**Tree numbers:** - D12.776.157.687.450 - D12.776.260.260 - D12.776.660.720.462 - D12.776.930.317

**Synonyms:** - Heat Shock Transcription Factor