Irinotecan

**Definition:** A semisynthetic camptothecin derivative that inhibits DNA TOPOISOMERASE I to prevent nucleic acid synthesis during S PHASE. It is used as an antineoplastic agent for the treatment of COLORECTAL NEOPLASMS and PANCREATIC NEOPLASMS.

**Tree numbers:** - D03.132.151.425

**Synonyms:** - Camptothecin-11 - Irrinotecan