Oxaliplatin

**Definition:** An organoplatinum complex in which the platinum atom is complexed with 1,2-diaminocyclohexane, and with an oxalate ligand which is displaced to yield active oxaliplatin derivatives. These derivatives form inter- and intra-strand DNA crosslinks that inhibit DNA replication and transcription. Oxaliplatin is an antineoplastic agent that is often administered with FLUOROURACIL and FOLINIC ACID in the treatment of metastatic COLORECTAL NEOPLASMS.

**Tree numbers:** - D02.257.750

**Synonyms:** - 1,2-Diamminocyclohexane(trans-1)oxolatoplatinum(II) - L-OHP Cpd - Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1) - Oxalato-(1,2-cyclohexanediamine)platinum II - Oxaliplatin, (SP-4-2-(1R-trans))-isomer - Oxaliplatine - 1,2-Diaminocyclohexane Platinum Oxalate - Platinum(II)-1,2-cyclohexanediamine Oxalate