Niemann-Pick C1 Protein

**Definition:** A transmembrane intracellular lipid transporter that helps trafficking lipids, particularly cholesterol, from late endosome/lysosome to the ER and plasma membrane. It may also play a role in other cellular cholesterol homeostasis and is an endosomal entry receptor for filoviruses including EBOLAVIRUS. Mutations in the NPC1 are associated with type C NIEMANN-PICK DISEASE.

**Tree numbers:** - D12.776.157.530.594 - D12.776.543.585.594 - D12.776.543.750.058.250 - D12.776.543.750.830.235 - D12.776.624.776.633.250

**Synonyms:** - NPC1 Protein