Leflunomide

**Definition:** An isoxazole derivative that inhibits dihydroorotate dehydrogenase, the fourth enzyme in the pyrimidine biosynthetic pathway. It is used an immunosuppressive agent in the treatment of RHEUMATOID ARTHRITIS and PSORIATIC ARTHRITIS.

**Tree numbers:** - D03.383.129.385.475

**Synonyms:** - N-(4-Trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide