Anaplastic Lymphoma Kinase

**Definition:** A receptor tyrosine kinase that is essential for development and differentiation of the nervous system in response to secreted growth factors. It phosphorylates the first tyrosine of the Y-x-x-x-Y-Y motif of targets that include PROTO-ONCOGENE PROTEINS C-CBL; INSULIN RECEPTOR SUBSTRATE-1; and MITOGEN-ACTIVATED PROTEIN KINASES, leading to activation of the MAPK signaling pathway and cell proliferation. A chromosomal aberration involving the ALK gene results in its constitutive expression in some cases of NON-HODGKIN LYMPHOMA.

**Tree numbers:** - D08.811.913.696.620.682.725.400.002 - D12.776.476.568.400.002 - D12.776.543.750.630.002

**Synonyms:** - NPM-ALK - ALK Kinase - Nucleophosmin-Anaplastic Lymphoma Kinase - ALK Tyrosine Kinase Receptor - CD246 Antigen - Anaplastic Lymphoma Receptor Tyrosine Kinase