Parthanatos

**Definition:** A type of regulated cell death initiated by hyperactivation of POLY (ADP-RIBOSE) POLYMERASE-1 (PARP-1) as a consequence of DNA DAMAGE; OXIDATIVE STRESS; HYPOXIA; HYPOGLYCEMIA; or INFLAMMATION. This leads to DNA FRAGMENTATION and CHROMATIN condensation.

**Tree numbers:** - G04.146.954.750

**Synonyms:** - PARP-1-Dependent Cell Death - PARP-Dependent Cell Death