Mitochondrial Transmembrane Permeability-Driven Necrosis

**Definition:** A form of regulated cell death that is initiated by specific perturbations of the intracellular microenvironment such as severe OXIDATIVE STRESS and cytosolic CALCIUM overload, which result in osmotic breakdown of the MITOCHONDRIAL MEMBRANES.

**Tree numbers:** - G04.146.954.393

**Synonyms:** - Mitochondrial Transmembrane Permeability-Driven Cell Death