Protein-Arginine Deiminase Type 1

**Definition:** A peptidylarginine deiminase isoenzyme. It is a post-translational modification enzyme that catalyzes the conversion of protein-bound ARGININE residues to CITRULLINE residues in a CALCIUM ion-dependent manner. It functions within the epidermis, targeting INTERMEDIATE FILAMENTS; KERATINS; and filaggrin for CITRULLINATION to promote epidermal cornification.

**Tree numbers:** - D08.811.277.721.250

**Synonyms:** - Peptidylarginine Deiminase Type I - PAD Type I - Peptidyl Arginine Deiminase Type 1 - Peptidyl Arginine Deiminase Type I - Protein Arginine Deiminase Type 1 - Protein Arginine Deiminase Type I - Protein-Arginine Deiminase Type I - Peptidylarginine Deiminase I - Protein Arginine Deiminase 1 - PADI1 Protein - Peptidylarginine Deiminase Type 1