Clonal Hematopoiesis

**Definition:** Expansion of blood cells arising from mutant HEMATOPOIETIC STEM CELLS often related to aging. Mutations on epigenetic regulator genes are common in clonal hematopoiesis and may be a risk factor for HEMATOLOGIC NEOPLASMS and other cardiovascular diseases. When variant allele fraction is at least 2% and is present in the absence of severe cytopenias it is referred to as clonal hematopoiesis of indeterminate potential (CHIP).

**Tree numbers:** - G04.152.825.207 - G04.375.500 - G05.158.500 - G09.188.343.207