Mitochondrial Permeability Transition Pore

**Definition:** A multiprotein inner mitochondrial complex which opens only under certain pathological conditions (e.g., OXIDATIVE STRESS) uncoupling the membrane leading to APOPTOSIS and MITOCHONDRIAL TRANSMEMBRANE PERMEABILITY-DRIVEN NECROSIS particularly in CARDIOMYOCYTES during MYOCARDIAL REPERFUSION INJURY.

**Tree numbers:** - D05.500.437 - D12.776.543.585.475.563 - D12.776.575.750.563

**Synonyms:** - Mitochondrial Permeability Transition Pore (mPTP) - mPTP Protein - Mitochondrial Megachannel