Angiotensin-Converting Enzyme 2

**Definition:** A transmembrane glycoprotein with an extracellular catalytic domain which functions as a carboxypeptidase. It cleaves a single C-terminal residue from a distinct range of substrates. The catalytic efficiency is 400-fold higher with ANGIOTENSIN II as a substrate than with ANGIOTENSIN I. Angiotensin-converting enzyme 2 is also is a functional receptor for the spike glycoprotein (SPIKE PROTEIN, CORONAVIRUS) of the CORONAVIRUSES SARS-COV, SARS-COV2, and HCOV-NL63.

**Tree numbers:** - D08.811.277.656.350.245.042

**Synonyms:** - Angiotensin-Converting Enzyme-Related Carboxypeptidase - Angiotensin Converting Enzyme 2 - ACE2 Enzyme - ACE2 Angiotensin-Converting Enzyme Protein 2 - ACE-Related Carboxypeptidase - ACE2 Protein