Promyelocytic Leukemia Nuclear Bodies

**Definition:** Spherical intranuclear membraneless bodies nucleated by PROMYELOCYTIC LEUKEMIA PROTEIN and various other proteins containing small ubiquitin-related modifier (SUMO) interaction motif (SIM) and/or sumoylated proteins (e.g., Sp100 protein). Promyelocytic leukemia nuclear bodies regulate posttranslational modifications of partner proteins (e.g., SUMOYLATION) which in turn lead to modulation of various biological processes.

**Tree numbers:** - A11.284.430.106.279.345.574.875

**Synonyms:** - Promyelocytic Leukemia Nuclear Body - Promyelocytic Leukemia Protein Bodies - PML Nuclear Bodies - Promyelocytic Leukemia Protein Body - PML Bodies - PML NBs