Senescence-Associated Secretory Phenotype

**Definition:** A paracrine pro-inflammatory phenotype developed in senescing cells. The senescence-associated secretory phenotype (SASP) results from the inflammatory, proteolytic and growth factor enriched SECRETOME of many types of senescent cells which leads to tissue repair or tissue and organ damage over time and links SASP to age-related disorders.

**Tree numbers:** - G04.043.445 - G07.345.124.130.445

**Synonyms:** - Senescent Cell SASP