Defective Interfering Viruses

**Definition:** Naturally occurring or synthetically made defective mutant viral genomes and particles which are incompetent in independent replication and interfere with normal VIRUS REPLICATION. Some synthetic defective interfering genomes may stimulate INNATE IMMUNE RESPONSE and are candidates for potential vaccine and therapeutic approaches for virus infections.

**Tree numbers:** - B04.265.135

**Synonyms:** - Defective Interfering Particles