Shelterin Complex

**Definition:** A TELOMERE cap complex consisting of telomere-specific proteins in association with telomeric DNA such as telomeric dsDNA-sDNA junction. They are involved in the protection of chromosome ends and TELOMERASE regulation and play a role in CELLULAR SENESCENCE and ageing-related pathology. In general it consists of six mostly TELOMERE-BINDING PROTEINS (POT1, RAP1, TIN2, TPP1, TRF1, and TRF2).

**Tree numbers:** - A11.284.430.106.279.345.190.160.845.500 - D05.500.918 - D12.776.260.735.625 - D12.776.660.235.700.625 - D12.776.664.981 - G05.360.160.845.500

**Synonyms:** - POT1-TPP1 Shelterin Complex - Telomere POT1-TPP1 Complex - Telosome