Gamma Secretase Inhibitors and Modulators

**Definition:** Agents that suppress GAMMA-SECRETASE by inhibiting or modulating its activities. Targeted enzymatic activities include its involvement in accumulation of toxic AMYLOID BETA-PEPTIDES (e.g., Aβ42) in ALZHEIMER DISEASE and activation of NOTCH RECEPTOR mediated SIGNAL PATHWAYS in certain cancer types.

**Tree numbers:** - D27.505.519.389.315

**Synonyms:** - GS Inhibitors and Modulators