M Cells

**Definition:** A distinct lineage of epithelial cells, present in MUCOSAL TISSUE, that is responsible for the immune sensing and capture of luminal bacteria and other microparticles. They deliver these microparticles, via TRANSCYTOSIS, to lymphoid tissue for efficient mucosal as well as systemic immune responses. Inflammation-induced M cells arising in response to inflammatory conditions may provide microbial access to tissues without normal M cell-associated immune surveillance tissue.

**Tree numbers:** - A10.615.550.522 - A11.436.578

**Synonyms:** - Microfold Cells