Proteolysis Targeting Chimera

**Definition:** Bifunctional molecules that are designed to recruit E3 UBIQUITIN LIGASE to a specific target protein. Proteolysis targeting chimera consist of a target protein ligand connected via a linker to an E3 ligand. They promote association of E3 with specific target proteins tagged for degradation via the PROTEASOME.

**Tree numbers:** - D27.720.470.410.210.500

**Synonyms:** - PROTACs - PROTAC Proteolysis Targeting Chimera - Proteolysis Targeting Chimeras