Gasdermins

**Definition:** A family of pore-forming effector proteins that cause membrane permeabilization and PYROPTOSIS.. Gasdermin-induced pyroptosis plays a prominent role in many HEREDITARY DISEASES and autoinflammatory disorders as well as in CANCER.

**Tree numbers:** - D12.776.157.530.400.353 - D12.776.543.550.450.464 - D12.776.543.585.400.464

**Synonyms:** - Cancer Associated Gasdermin-Domain Containing (GSDMDC) Proteins