Pradimicins and Benanomicins

**Definition:** Polycyclic aromatic polyketides with pentacyclic angular dihydrobenzo(a)naphthacenequinone skeletons. Pradimicin- and related benanomicin-type polyphenols are produced by Actinobacteria, e.g., ACTINOMADURA, using type II polyketide synthase involving condensation of one acetyl-CoA and nine malonyl-CoA. Pradimicins and benanomicins have an amino acid (e.g., D-ALANINE) and often a 5-O-sugar and bind to terminal D-mannosides of the cell wall of various fungi, e.g., CANDIDA. In addition to antifungal activity many pradimicins and benanomicins have anti-HIV activities.

**Tree numbers:** - D02.455.426.559.847.562.050.825 - D02.540.576.750 - D02.806.550.469 - D04.345.674.750 - D04.615.562.050.825 - D09.408.051.059.825

**Synonyms:** - Pradimicin-Like Polyketides - Pradimicin-Type Polyphenols - Benanomicins and Pradimicins