Neuroligins

**Definition:** Postsynaptic cell-adhesion molecules that bind presynaptic NEUREXINS to form calcium-dependent trans-synaptic adhesions. Neuroligins recruit synaptic scaffolding proteins (e.g., PSD-95) via their PDZ DOMAIN. The distribution and interaction with neurexins are regulated by ALTERNATIVE SPLICING. Alterations in genes encoding neuroligins or neurexins are associated with cognitive diseases such as AUTISM SPECTRUM DISORDER.

**Tree numbers:** - D09.400.430.890.200.250.520.894 - D12.776.395.550.200.250.520.894 - D12.776.543.550.200.250.520.894 - D12.776.631.641 - D23.050.301.350.250.520.894

**Synonyms:** - Neuroligin