OEIS Complex

**Definition:** A combination of defects comprising OMPHALOCELE, exstrophy of the cloaca, ANUS IMPERFORATE, and spinal defects. This rare complex is thought to represent the most severe end of a spectrum of birth defects, the exstrophy-epispadias sequence, which, in order of increasing severity, includes phallic separation with EPISPADIAS, pubic diastasis, EXSTROPHY OF THE BLADDER, and CLOACAL EXSTROPHY. (From OMIM 258040)

**Tree numbers:** - C16.614.660

**Synonyms:** - Omphalocele Exstrophy Imperforate Anus - Omphalocele Exstrophy Imperforate Anus Spinal Defects Complex - Omphalocele, Exstrophy Of The Bladder, Imperforate Anus, Spinal Abnormalities - Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, and Spinal Defects - Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects - Omphalocele-Exstrophy-Imperforate Anus-Spinal Defects Complex