Bioisosterism

**Definition:** A strategy used in PHARMACEUTIC CHEMISTRY where one part of a molecule is replaced with a different one that has similar physical or chemical properties, but with the aim of enhancing the biological activity, stability, or safety of the molecule.

**Tree numbers:** - H01.158.703.007.001

**Synonyms:** - Bioisosteric Replacement - Bioisosteric Substitution - Bioisosteric Design - Bioisosteric Modification