UGT1A1 Enzyme

**Definition:** Glucuronosyltransferase encoded by UGT1 complex which encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. It catalyzes reactions where lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility and excretion into either urine or bile. UGT1A1enzyme is essential for elimination and detoxification of drugs, xenobiotics and metabolites.

**Tree numbers:** - D08.811.913.400.450.480.751

**Synonyms:** - 1-Naphthol UDP-Glucuronosyltransferase - Bilirubin Uridine-Diphosphoglucuronosyl Transferase 1A1 - Phenol GCStransferase - Phenol UDP-Glucuronosyltransferase - UDP Glucuronosyltransferase 1A1 - UDP-Glucuronosyltransferase 1A1 - UGT1A1 Protein