Myocilin

**Definition:** A secreted glycoprotein that controls activation of signaling pathways in adjacent cells (PARACRINE COMMUNICATION) for processes that include CELL ADHESION; CELL MIGRATION; and organization of the CYTOSKELETON. It is primarily expressed in the RETINA and variants in the myocillin gene cause GLAUCOMA 1, OPEN ANGLE, A.

**Tree numbers:** - D12.644.276.856 - D12.776.306.458 - D12.776.467.851 - D23.529.836

**Synonyms:** - GLC1A Protein - MYOC Protein - TIGR Protein - Trabecular Meshwork-induced Glucocorticoid Response Protein