MAP-Kinase-Activated Kinase 2

**Definition:** A serine-threonine protein kinase that functions in many different processes including the cellular response to PHYSIOLOGICAL STRESS, production of CYTOKINES; ENDOCYTOSIS; CYTOSKELETON dynamics, CELL MIGRATION; and CELL PROLIFERATION. It is phosphorylated by MAPK14 in response to stress, and in turn phosphorylates substrates at a SERINE that is preceded by a large hydrophobic amino acid.

**Tree numbers:** - D08.811.913.696.620.682.700.550 - D12.776.476.563.550

**Synonyms:** - Heat Shock Protein 27 Kinase - Heat-Shock Protein 27 Kinase - HSP 27 Kinase - MAP-Kinase-Activated Protein Kinase 2 - MAPK Activated Protein Kinase 2 - MAPKAP Kinase 2 - MAPKAP Kinase-2 - MAPKAPK-2 - MAPKAPK2