Adrenal Hyperplasia, Congenital

**Definition:** A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.

**Tree numbers:** - C12.050.351.875.253.090.500 - C12.200.706.316.090.500 - C12.800.316.090.500 - C16.131.939.316.129.500 - C16.320.033 - C16.320.565.925.249 - C18.452.648.925.249 - C19.053.440 - C19.391.119.090.500

**Synonyms:** - Congenital Adrenal Hyperplasia - Hyperplasia, Congenital Adrenal