5-Aminolevulinate Synthetase

**Definition:** An enzyme of the transferase class that catalyzes condensation of the succinyl group from succinyl coenzyme A with glycine to form delta-aminolevulinate. It is a pyridoxyal phosphate protein and the reaction occurs in mitochondria as the first step of the heme biosynthetic pathway. The enzyme is a key regulatory enzyme in heme biosynthesis. In liver feedback is inhibited by heme. EC 2.3.1.37.

**Tree numbers:** - D08.811.913.050.276

**Synonyms:** - Aminolevulinic Acid Synthetase - delta-Aminolevulinate Synthase - delta-Aminolevulinic Acid Synthetase - 5-Aminolevulinate Synthase