Amitriptyline

**Definition:** Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.

**Tree numbers:** - D02.455.426.559.847.181.384.100 - D04.615.181.384.100