Pain Insensitivity, Congenital

**Definition:** A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from non-noxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)

**Tree numbers:** - C10.668.829.700 - C16.320.775

**Synonyms:** - Congenital Indifference to Pain - Congenital Insensitivity To Pain - Congenital Pain Indifference - Congenital Pain Insensitivity - Insensitivity To Pain, Congenital - Insensitivity, Congenital Pain - Pain Indifference, Congenital - Analgesia, Congenital - Channelopathy-Associated Insensitivity To Pain - Congenital Analgesia