Antibody-Dependent Cell Cytotoxicity

**Definition:** The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.

**Tree numbers:** - G12.287.070

**Synonyms:** - Cytotoxicity, Antibody-Dependent Cell - ADCC - Cell Cytoxicity, Antibody-Dependent