Aromatase

**Definition:** An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.

**Tree numbers:** - D08.244.453.489.500 - D08.244.453.915.099 - D08.811.682.690.708.170.447.500 - D08.811.682.690.708.170.915.099 - D12.776.422.220.453.489.500 - D12.776.422.220.453.915.099

**Synonyms:** - Estrogen Synthetase - Estrogen Synthase - Cytochrome P450 19 - CYP19 - Cytochrome P-450(AROM) - CYP 19 - Cytochrome P-450 CYP19 - P450AROM - Androstenedione Aromatase - CYP19 Protein