Cholesterol 7-alpha-Hydroxylase

**Definition:** A membrane-bound cytochrome P450 enzyme that catalyzes the 7-alpha-hydroxylation of CHOLESTEROL in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP7, converts cholesterol to 7-alpha-hydroxycholesterol which is the first and rate-limiting step in the synthesis of BILE ACIDS.

**Tree numbers:** - D08.244.453.890.500 - D08.244.453.915.200 - D08.811.682.690.708.170.890.500 - D08.811.682.690.708.170.915.200 - D12.776.422.220.453.890.500 - D12.776.422.220.453.915.200

**Synonyms:** - Cholesterol 7alpha-Hydroxylase - Cholesterol-7-Hydroxylase - Cytochrome P-450 CYP7 - CYP 7 - Cytochrome P450 7 - CYP7 - CYP 7A - Cholesterol 7-alpha-Monooxygenase - CYP7A