Microbial Collagenase

**Definition:** A metalloproteinase which degrades helical regions of native collagen to small fragments. Preferred cleavage is -Gly in the sequence -Pro-Xaa-Gly-Pro-. Six forms (or 2 classes) have been isolated from HATHEWAYA HISTOLYTICA that are immunologically cross-reactive but possess different sequences and different specificities. Other variants have been isolated from Bacillus cereus, Empedobacter collagenolyticum, Pseudomonas marinoglutinosa, and species of Vibrio and Streptomyces. EC 3.4.24.3.

**Tree numbers:** - D08.811.277.656.300.480.205.500 - D08.811.277.656.675.374.205.500

**Synonyms:** - Clostridiopeptidase A - Clostridium histolyticum Collagenase - Collagenase Clostridium histolyticum - Collagenase, Microbial - Collalysine - Nucleolysin