Dactinomycin

**Definition:** A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)

**Tree numbers:** - D03.633.300.200 - D04.345.566.252 - D12.644.641.252

**Synonyms:** - Actinomycin D - Meractinomycin