Deoxyribonuclease I

**Definition:** An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

**Tree numbers:** - D08.811.277.352.335.350.250

**Synonyms:** - DNase I - Pancreatic DNase - Thymonuclease - DNAase I - DNA Endonuclease