Diphtheria Toxin

**Definition:** An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.

**Tree numbers:** - D08.811.913.400.725.115.220 - D23.946.123.305

**Synonyms:** - Corynebacterium Diphtheriae Toxin - Toxin, Corynebacterium Diphtheriae