DNA Polymerase I

**Definition:** A DNA-dependent DNA polymerase characterized in prokaryotes and may be present in higher organisms. It has both 3'-5' and 5'-3' exonuclease activity, but cannot use native double-stranded DNA as template-primer. It is not inhibited by sulfhydryl reagents and is active in both DNA synthesis and repair.

**Tree numbers:** - D08.811.913.696.445.308.300.225

**Synonyms:** - DNA Pol I - DNA Polymerase alpha - DNA-Dependent DNA Polymerase I - Klenow Fragment